Impact of the fetuin gene polymorphisms in coronary artery calcification and mortality of patients with chronic kidney disease and renal transplant

Fetuin A is a major systemic inhibitor of vascular calcifications. The aim this study was to examine association single nucleotide polymorphisms (SNP) in the gene for fetuin-A with serum levels, coronary arteries calcification (CAC) and mortality renal transplant (RT) chronic kidney (CKD) patients. This included 88 patients (42 stable RT at least 6 months after transplantation 46 CKD patients, stage 2-5 not requiring dialysis) followed five years. Detection analysis fetuin positions C742T (Thr248Met; rs4917) C766G (Thr256Ser; rs4918) were performed using PCR method. Respondents allele 742T had same time 766G. Combined genotypes TT/GG lower levels than CT /CG CC/CC. Predictors CAC univariate age (p=0,000), (p=0.011) rs 4917 polymorphism (p=0.021) while multivariate determined (p=0.001) (p=0.031). Patients who homozygous variant 766G (combined genotype TT/GG) lowest survival rate. Our results suggest that associated higher occurrence rate